Purely my opinion…..
The advantages in velocity, energy and high B.C. bullets are seldom realized since, even in the open expanses of the west, 95% or better of all shots on game are under 400 yards.
Not til past 400 yards does any magnum start to significantly pull away from standard cartridges. Even then, the trajectory, ballistic and energy numbers have little to no bearing on lethality from any well placed shot. Bullet design and impact velocity is another matter, with impacts on bone being a crap shoot with most any caliber (primarily due to failure and deflection). That said, most N.A. hunting can be handled with calibers .243-.308 diameters, in cartridges with case capacities of 35-75 grains volume. It begins to be a point of diminishing returns really past 55 or so grains (grains of weight) in my opinion. Plain, vanilla cartridges utilizing ‘06 Springfield or .308 Winchester cases- sized up or down from .243 to .358- are perfectly adequate. A 300-400 yard shot isn’t difficult to pull off with decent optics, and that’s well under these cartridges range in killing ability.