I'm a .45 shooter ( 45 Colt and C45S for CAS , 45 ACP for many years prior ) , and I have no plans to change.
Shooting the 45s carries it's own
penalties, cost of components and availability of large pistol primers in my area being the main ones.
And yes, I shoot those " mouse fart loads " with 160 grain bullets at 630 fps and 114 power factor. This allows me to shoot the larger caliber rounds at the smaller caliber cost. I think that recoil is the same or less than a moderately loaded .38 round, and less than a .357.
I've encountered only one KD target that this load wouldn't put down , and all the other shooters were having trouble with it also, but I believe it was the target, not the load.
I prefer the C45S cartridge over the Colt, but there are a few extra hoops to jump through to make the loading process work smoothly, but in the long run we'll worth it, IMHO.
But as said earlier, shoot whatever puts a smiling your face , it's all a matter of choice.
Choctaw