Same. Solidify your reloads, then file away.
Sure, it'll probably bring the value down - or at least limit the number of folks who'd even consider buying them, but I'm more concerned with where the bullet impacts. Since I have no aspirations to sell (how can you sell a Vaquero and upgrade to a better pistol?), I'm not willing to use Kentucky windage on the range to simply maintain gun value. Of course I'm just a new guy, so I need all the help I can get.
I have a lot more fun when I quit caring about cart dings on wood stocks, the bluing rubbing off barrels, or the modified height of a front sight.