Thank you all for the info!
Through my research I did read about the advantage of the slightly bottle-necked cartridges. And considering historical aspects, I would have much preferred the 44/40. The reason I specifically mentioned 45 colt is because that's what my SAA clone is in. Many might not be aware, but in MA we have some weird laws. FFLs in MA cannot sell or transfer you a pistol/revolver unless its specifically mentioned in the MA approved firearms list. This does not make unlisted pistols/revolvers illegal though. The only SAA clones currently on the list are Ruger Vaqueros and Blackhawks, of which only 44/40 is approved only in Blackhawks. The only way around this is through personal transfers from people who moved into the state with firearms not listed. So when I saw an Uberti SAA clone for sale locally I jumped on it. I got it through historical interests, not to use it in matches, so the 4 clicks and a more correct rear sight was important to me. So unless someone in MA wants to trade with me their 44/40 SAA clone, I have to stick with 45 colt for now.