try to plan to arrive a day early, to site see and just take it easy. Two full days of travel wiped me out. Also try to plan a down day on the return as well. Some how the travel back was more exhausting.
also, hydration and electrolytes. bring plenty of hydration packets from the drug store, or wherever, there are also places locally to get these supplies. You can use google maps to look around the neighborhood you'll be staying at to find restaurants, groceries, pharmacies, etc.